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Cetirizine (CTZ) and Salbutamol (SAL) are co-formulated for treatment of common cold and allergy [1]. Cetirizine (CTZ, Figure 1a) is [2-[4-[(4-Chlorophenyl) phenylmethyl]-1–piperazinyl] ethoxy] acetic acid). It is long acting antihistaminic which used for relief of allergic conditions [2]. The BP described non-aqueous potentiometric titration method for CTZ determination [3]. Previously published methods described for determinations of CTZ include HPLC either in pharmaceutical preparations [4-6] or in biological fluids [7,8], fluorimetry [9] and spectrophotometry [10].

sm analytical and bioanalytical techniques

A Validated Reversed Phase HPLC Method for Simultaneous Determination of the antihistaminic Cetirizine and Beta2-adrenergic agonist Salbutamol in their Co-formulated Tablets