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Single-case experiments are increasingly popular in the behavioral sciences. Due to their flexibility, single-case designs can be customized to test a variety of experimental hypotheses. We were interested inusing a single-case experimental approach to test whether pain thresholds can be influenced by Pavlovianclassical conditioning. Following the example of earlier studies into this topic, we planned to measurewhether participants would more frequently report specific electrocutaneous stimuli as painful whenthey were presented with specific vibrotactile stimuli that had previously been associated with painfulelectrocutaneous stimuli. First, we decided on a mean difference effect size measure derived from theSensation and Pain Rating Scale ratings for the electrocutaneous stimuli provided by the participants. Next,we discussed several possible single-case designs and evaluated their benefits and shortcomings. Then,we ran pilot tests with a few participants based on the possible single-case designs. We also conducteda simulation study to estimate the power of a randomization test to test our hypothesis using differentvalues for effect size, number of participants, and number of measurements. Finally, we decided on asequentially replicated AB phase design with 30 participants based on the results from the pilot testsand the power study. We plan to implement this single-case design in a future experiment to test ourhypothesis

Classical Conditioning for Pain: The Development of a Customized Single-Case Experimental Design