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Received Date: Dec 24, 2019 / Accepted Date: Dec 31, 2019/ Published Date: Jan 02, 2020 Abstract Introduction: Coping with perinatal depression in healthcare systems worldwide has been so far more or less insufficient and there is a huge need of implementing new prevention and treatment options. Methods: Literature review has been done to assess state of current knowledge on microbiome changes in perinatal period and form potential clinical implementation of these information. Results: Intestinal microbiota can influence central nervous system functions and this relation seems bidirectional. The diversity of gut microbiota has emerged to play a significant role in the occurrence of mood and anxiety disorders, but this relationship is poorly understood in perinatal period. Studies have shown a reduced phylogenetic diversity and species richness of gut microbiota in depressed pregnant women, and a significant association between antibiotic exposure during the peripartum period and development of depressive symptoms. Even though breast milk is the fundamental source of microbes colonizing the infant’s gut, there is very little known about possible human milk microbiota changes in depressed women. Our microbiome may be modulated by numerous circumstances, especially diet but no current microbiome-specific dietary recommendations exist. Conclusions: Future research in the relationship between the gut microbiota, diet and PND holds tremendous potential to be integrated in clinical practice. The impact of breast milk microbiota on infant development and health could have important implications for early-life prevention of chronic conditions. Given that bacterial functions are conserved across taxonomic groups, incorporating microbial function biomarkers may be more productive than a purely taxonomic approach to understanding the microbiome in diseases.

Is there a connection between fecal and milk microbiota composition and function and perinatal depression? Rationale for future studies