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ABSTRAK Furosemida merupakan diuretik golongan sulfonamida yang praktis tidak larut dalam air dan mempunyai ketersediaan hayati yang kurang baik. Pada penelitian sebelumnya pembentukan kompleks furosemida dengan (PVP) meningkatkan disolusi dan ketersediaan hayati furosemida secara bermakna (P<0,05). Oleh karena itu perlu dilakukan penelitian tentang bagaimana formulasi untuk pembuatan tablet furosemida yang dibuat dari kompleks furosemida-PVP. Tablet furosemida-PVP dibuat dengan metode granulasi basah. Masing-masing formula memiliki kadar PVP yang bervariasi, pada formula II 25% dan formula III 50% dari zat aktifnya yaitu furosemida, formula I sebagai kontrol dipakai tablet furosemida®. Pada formula II dan III dilakukan uji sifat fisik granul, serta uji sifat fisik tablet dan uji disolusi untuk semua formula. Hasil uji sifat fisik tablet dan uji disolusi diuji statistik menggunakan perangkat lunak SPSS. Hasil uji sifat alir granul untuk setiap formula memiliki waktu alir kurang dari 10 detik dan sudut diamnya kurang dari 42° sehingga memiliki sifat alir granul yang baik. Uji sifat fisik tablet diperoleh hasil yang memenuhi syarat. Kata kunci : Furosemida, Kelarutan, Kompleksasi, Disolusi ABSTRACT Furosemide is a diuretic sulfonamid groups which not in soluble practically and has poor bioavalaibility. The research of complex formation between furosemide and PVP increased the dissolution and bioavalaibility significantly with 95% reliable level. The interaction of furosemide-PVP complex were determined by infrared spectrum which show the string of functional compounds couse by complecxation. The tablet of furosemide-PVP made by wet granulation. Each formulas consist of various contain of PVP as carrier. On formula II 25% and formula III 50% from its active compound that is furosemide, formula I use as control. Each formulas II and III were evaluated its physical properties of granules and physical properties evaluation of tablet. Statistic done by SPSS. The result of flow properties of granules test for each formulas has flow time less than 10 second and the repose of angle were less than 42o it concluded that is has good flow properties. From physical properties test resulted were fulfill the requirements. Keywords : Furosemide, soluble, Complecxation, Dissolution

FORMULASI TABLET FUROSEMIDA DENGAN PENAMBAHAN PVP SEBAGAI ZAT PEMBENTUK KOMPLEKS TERHADAP SIFAT FISIK TABLET