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Compound UK-3A is a known active compounds for anti-cancer and anti-fungal. UK-3A compound was isolated as a minor component of the mycelium of Streptomyces sp . 512-02 and have active groups hydroxyl, amide, and dilakton nine rings were shown to actively inhibit the growth of bacteria and cancer cells . To synthesize these compounds require complicated synthesis process and longer periods of time. In this study synthesized compound UK-3A analogue that is 6-hydroxy-N-octylnicotinamide modifications based active group of compounds UK-3A . Modification of active groups in the compound UK-3A analogue is possible to obtain compounds that have the same bioactivity or more active than the parent compound UK-3A and simple with less reaction . Both compounds synthesized were identified by TLC, FTIR, 1H-NMR, and 13C-NMR . Test results of brine shrimp lethality bioactivity test method (BSLT) of the two compounds obtained LC50 values of 41,14 mg / mL.

SINTESIS DAN UJI BIOAKTIVITAS SENYAWA ANALOG UK-3A 6-HIDROKSI-N-OKTILNIKOTINAMIDA