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Stroke is a cerebral vascular disease characterized by tissue death due to reduced blood flow and oxygen to the brain. Patient suffered from stroke may take many medication (polypharmacy) which may increase the risk of drug. The purpose of this study was to describe the actual drug interactions that occur in stroke patients at Rumah Sakit Pusat Otak Nasional. This study was an observational study conducted prospectively from May-July 2016 at the Stroke Care Unit (SCU) at Rumah Sakit Pusat Otak Nasional. We used purposive sampling technique and obtained 80 patients who appropriate to the inclusion and exclusion criteria. The results showed that the potential drug interactions that occurred in stroke patients at Rumah Sakit Pusat Otak Nasional were 178 events, but the actual drug interactions that occurred were only 3 events. The three occurrences of drug interactions were experienced by 5 patients (6.25%). The interacting drugs were Digoxin with Captopril (1.25%), Phenytoin with Nimodipine (2.5%) and Captopril with Furosemide (2.5 %). Proper treatment of the actual occurrence of drug interactions has been carried out by the clinician, so that patients get the optimal therapeutic effect.

KAJIAN INTERAKSI OBAT PADA PASIEN STROK DI RUMAH SAKIT PUSAT OTAK NASIONAL