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Dewandaru (Eugenia uniflora L.) is one of the medicinal plants that have been widely used for traditional medicine. Cigarettes are addictive substances that can threaten human survival. The main toxins in cigarettes are nicotine, tar and carbon monoxide (CO). Cigarette smoke is a major cause of lung damages. One of the damages is oxidative stress. Dewandaru contains flavonoid compounds that can be used as antioxidants. This study aims to determine the n-Butanol extract of dewandaru fruit on the lung histopathology of male mice exposed to cigarette smoke. This was an experimental study with randomized post-test only with control group design, which used 30 male mice divided into three groups. Group I as a control group was given exposure to cigarette smoke and a CMC solution of 0.5 ml / day. Group II and III as the treatment group were given 30 minutes / day of cigarette smoke exposure for 20 days and given n-Butanol extract of dewandaru fruit at a dose of 100 mg / KgBW and a dose of 200 mg / KgBW on the third day until the 10th day. On Day 21 the mice were sacrificed and dissected for their lungs, making histopathological preparations, and lung histopathology examinations. The results of the research data were analyzed qualitatively. It was found that the lung histopathological features of male mice which were given n-Butanol extract of dewandaru fruit showed an improvement in cell tissue. The dose which showed the most improvement was 200 mg / KgBW.

jurnal ilmiah medicamento

PENGARUH PEMBERIAN EKSTRAK n-BUTANOL BUAH DEWANDARU (Eugenia uniflora L.) TERHADAP GAMBARAN HISTOPATOLOGI PARU MENCIT (Mus muscullus) JANTAN YANG TERPAPAR ASAP ROKOK