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The leaves of Moringa oleifera have exceptional nutritional qualities and are used in traditional medicine to treat several diseases including anemia. This study is to propose a formulation for the optimal use of M. oleifera leaf powder in the treatment of anemia in rats. Phenylhydrazine (40 mg/kg) was administered intraperitoneally for 2 days to induce anemia in rats (Rattus norvegicus). The animals were divided into six groups of 6 rats each and treated orally from day D2 to D28. Rats groups 1, 2, 3 and 4 were treated orally, respectively with 400, 800 and 1600 mg/kg of M. oleifera aqueous extract of leaves (AEMo) and Ranferon. Groups 5 and 6 were fed ad libitum with diets containing 50% (P50) and 100% (P100) of M. oleifera leaves as a substitute for soybean meal, respectively. Red blood cell (RBC) parameters such as RBCs, hemoglobin (Hb), hematocrit (Ht), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) were analyzed on days D0, D2, D5, D14 and D28. Results showed a prevalence of 0% in anemic rats treated with P50, AEMo 1600 mg/kg and Ranferon versus 16.67% in those treated with P100, AEMo 400 and 800 mg/kg at D28. In addition, P50, AEMo 1600 mg/kg and Ranferon significantly (p ˂ 0.001) increased RBCs, Hb, Ht with total recovery especially RBCs and Ht in anemic rats treated with P50 and Ranferon. In conclusion, the incorporation in small quantities of M. oleifera leaf powder as a substitute for soybean meal has a better efficacy on anemia than the total leaf extract of the same plant.

Comparative Effects Between A Total Aqueous Extract and A Diet Enriched with Moringa oleifera Leaves in Wistar Rats with Anemia