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Maternal exposure to environmental factors has been reported to be associated with birth defects. Congenital heart defects are the most common and are associated with high morbidity and mortality in offspring. However, the relation of maternal rheumatic heart disease to congenital heart defects in the offspring is a rare event not yet reported. The authors report 2 cases of infants with congenital heart defects born from mothers with rheumatic heart disease. This study highlights factors related to congenital heart defects in both newborns.

asploro journal of biomedical nd clinical  case reports

Factors Related to Congenital Heart Disease in Offspring from Women with Rheumatic Heart Disease: Case reports from Moi Teaching and Referral Hospital, Eldoret, Kenya