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Vitamin D plays a role in regulating the immune system via Vitamin D receptors, expressed by T-helper cells (Th). Cathelicidin LL-37 is an antimicrobial peptide that acts as the primary barrier against the Mycobacterium tuberculosis bacterial infection, which is induced by calcitriol, the active form of Vitamin D3. Interferon gamma (IFN-γ) is a cytokine released by Th-1 cells, and is essential for the elimination of M. tuberculosis. This study aims to determine the state of, and correlation between, calcidiol, calcitriol, cathelicidin and IFN-γ levels, as well as other clinical factors among patients with Type 2 Diabetes Mellitus (T2DM) with active TB coinfection. Further analysis is also performed to study the differences between T2DM patients with active tuberculosis, latent TB and without TB infection.

jurnal respirologi indonesia

Specific levels of calcidiol, calcitriol, cathelicidin and interferon gamma in diabetic patients with TB infection in Jakarta, Indonesia; Case control study