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Objective: Aim of the study was to study in parallel changes in electrogustometric thresholds (EGM), in morphology and density of the fungiform papillae (fPap) and in vessels’ shape and density at the tip of the human tongue of patients receiving Captopril. Material and Methods: In 18 female subjects receiving Captopril (50mg, once per day) as Monotherapy against Hypertension EGM thresholds at the chorda tympani, at the soft palate were recorded bilaterally. Morphology and density of the fungiform papillae (fPap) and blood vessels’ density and morphology at the tip of the tongue were examined using contact endoscopy (CE). As control-group 18 healthy non-smokers female subjects of the same age group were also examined. Results: The evaluation of subjects treated with Captopril showed a higher EGM-thresholds as the subjects of the control-group. The difference between the density of patients’ fPap and that of the control-group was statistically significant. It is obvious that Captopril affects the shape and the vascularization of fPap. Captopril can affect seriously taste acuity. Conclusion: The present study provides data concerning the simultaneous changes in both EGM-Thresholds and shape and vascularization of fPap. The use of captopril seems to have a negative effect on them. Keywords: Captopril, contact endoscopy, electrogustometry, fungiform papillae, vascularization

The effect of Captopril on electrogustometry thresholds, tongue tip vascularization, density and form of the fungiform papillae in humans