English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Since February 2019 a new disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been devastating the world. As of today, 12 million people have been diagnosed with coronavirus disease-19 (COVID19) and more than 550,000 patients died. The US with 3 million infected patients and 132,000 deaths is the leading country followed by Brazil (1,2). In relation, approximately 200,000 confirmed cases have been detected in Turkey with 5,000 deaths which is low compared to several European Countries. Several reports have been coming about the clinical manifestations and blood biochemical results those might play an essential role for the estimation of the progress of the patients and the management of therapy. However, there is no specific treatment defined. Thus, the distribution of the clinical and demographic characteristics of COVID-19 in different regions seems to be important to prevent the spread of the disease. A recent study showed that SARS-CoV-2 have the ability to bind to angiotensin-converting enzyme 2 (ACE2) on cholangiocytes causing disruption in the cell functions and triggering a systemic inflammatory response led to liver injury (1). In addition, various studies revealed elevated levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes ranging from 14% to 53% (3,4). Furthermore, pathological findings have also indicated moderate microvesicular steatosis and mild lobular and portal activity (5). The present study aims to report the clinical and biochemical course of the patients hospitalized with COVID-19, and the importance of liver function test results on the course of the disease. Abstract

Changes in liver function in patients with covid-19 and the demographics of the disease in a mid-sized city of Turkey: A retrospective analysis