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Many substituted acridin-2-yl(phenyl) methanones have been successfully prepared in good yields by reacting functionally substituted aryl halides with many internal acetylenes in presence of a palladium catalyst Pd(dba)2. The end product of this reaction has also been synthesized via reaction of cis- and trans3-(2-chloro-6-methoxyquinolin-3-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one palladium complexes towards acetylene in an aqueous medium. This reaction was believed to proceed via region-selective arylpalladation of the acetylene and subsequent nucleophilic displacement of the palladium, which further produced vinylpalladium intermediates. The intermediates and the final products have been tested for broad-spectrum antibacterial and antibiofilm activities.

indian journal of pharmaceutical sciences

Synthesis of Acridin-2-yl(Phenyl)Methanone via Palladium Catalyzed Carboannulation of Internal Acetylene and Its Antibacterial and Anti-biofilms Activity