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This literature review aims to describe the risk factors affecting outcomes in pediatric acute lymphoblastic leukemia (ALL). ALL is the most common cancer among children and the most frequent cause of death from cancer in the population aged below 20 years of age. Obesity is a chronic problem in children that needs to be taken seriously in ALL. Several mechanisms are considered to play a role in the correlation between ALL and obesity. These include increased endogenous hormones (sex steroid hormones, insulin, and insulin growth factor-1) due to the accumulation of body fat, which plays an important role in controlling cell growth, differentiation and metabolism. Chronic inflammation also plays a role in generating cancer cells. Adipocyte cells are a potent source of inflammatory cytokines. Poor prognosis of pediatric patients with obesity is related to factors such as inadequate therapeutic doses, patients diagnosed under 1 year of age or above 10 years of age, as well as leukocyte count of over 50,000/mm.

Obesitas Sebagai Faktor Prognosis Buruk pada Anak dengan Leukemia Limfoblastik Akut