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In the present study, the effects of intralesion injections of beta-aminopropionitrile fumarate injections(BAPN-F) were assessed in the equine experimental tendinitis induced by collagenase. BAPN-F is a potent lathyrogen, which inhibits collagen cross-linking by irreversibly blocking the lysil oxidase enzyme, permitting more time for parallel reorientation of the repair tissue. Sixteen two-year old Arabian horses without any leg problems were selected for this study and divided into two groups: Group 1(rest) and Group 2 (exercise). Tendinitis was induced by injecting collagenase (0.5 ml; 2.5 mg/ml) on the superficial flexor tendon of both forelimbs. Twenty days after tendinitis was induced, intra1esiona1therapy was done by injecting BAPN-F (3 ml; 0.8 mg/ml) in one of the legs every other day until five treatments were completed. The contralatera1 limb received an injection of sa1ine at the same time period. The hea1ing process was monitored by clinical and sonographic examinations during the whole experiment. Results obtained indicate that beta-aminopropionitrile fumarate coupled with control1edloading improved scar remodeling and maturation of the tendon scarring.

Influência do fumarato de beta-aminopropionitrila associada ao exercício na cicatrização tendínea eqüina - Avaliação clínica e ultra-sonográfica