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Background: Reports suggest that HIV-infected patients have elevated D-dimer levels that may be related to chronic inflammation and coagulation abnormalities. Levels of D-dimer have also been reported to be higher in HIV treatmentnaïve patients compared to treatmentexperienced patients. HIV infection has also been associated with a decrease in the number of both CD4+ and CD8+ T-cells resulting primarily from a combination of increased apoptosis and decreased lymphopoiesis. Methods: Eighty (80) subjects attending HIV clinic at the University of Port-Harcourt Teaching Hospital, Port Harcourt, Rivers state who satisfied the inclusion criteria were enrolled into the study. A commercial assay kit; ELISA Kit for D-Dimer (D2D) (manufactured by Uscn Life Science Incorporated R USA) was used with a TC96+ ELISA microplate reader (manufactured by Ceco diagnostic R USA) to determine the D-dimer level. CD4 + T-cell count was evaluated using the Partec Cyflow counter-1, a single-platform, three-parameter (SSC plus two-colour fluorescence) desktop volumetric flow cytometer (manufactured by Sysmex Partec R Germany).Full blood count was carried out on the EDTA anticoagulated sample using the Horiba Abx Micros 60 Haematology Analyser (manufactured by Horiba instruments incorporated R USA). Results: The D-dimer level was found to be lower in HAARTexperienced subjects (288.35 ± 129.12 ng/ml) than HAART-naïve subjects (389.85 ± 217.61ng/ml.) (P= 0.013).The mean CD4+ T-cell count of HAART–naïve subjects was 379.33±287.25 cell/ul and for HAART–experienced subjects was 387.55±334.85 cell/ul. Their mean difference was not statistically significant (P=0.906). Conclusion: It was observed that there was no correlation between D-Dimer and CD4+ T-cell count in HAART-naive and experienced subjects.

To Determine the Correlation between D-Dimer and CD4+ T-Cell Count in HIV Treatment-Naive and Treatment-Experienced Patients in Port-Harcourt, Nigeria