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Objectives: The study was done to evaluate efficacy of chemiluminescent method (vizilite) as a screening test in detecting the malignant changes in potentially malignant lesions of oral cavity. Study also compares sensitivity and specificity of toludiene blue with chemiluminescent method. Materials & methods: 30 patients clinically diagnosed as potentially malignant lesions of oral cavity were recruited. After obtaining consent form, all patients were subjected chemiluminescent method and toludiene blue. All patients were then compared with histopathological results and statistically analyzed. Results: After histopathological results, Sensitivity and specificity of vizilite was found to be 66.6% and 71.4% respectively and that of toluidine blue was 77% and 87%. Conclusion: Although vizilite accentuated the visibility of the lesion but overall detection rate in patients was not significantly improved. Qualities like easy to perform, less time consuming and instant results concur with the properties of an ideal screening test but diagnostic propensity is questionable.

saudi journal of oral and dental research

Comparative Study to Determine the Efficacy of Chemi-Luminescent Method (Vizilite) and Toludine Blue Staining as a Screening Test in Oral Pre-Malignant Lesions