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Biclonal gammopathies manifestations (BGMs) are defined as a clonal proliferation of plasma cells or B-lymphoid progenitors that produces 2 different monoclonal proteins known as M-proteins or paraproteins. The aim of our study is to report and analyses the epidemiological, biological and clinical features of the cases of biclonal gammopathies diagnosed at the Hassan II University Hospital Center (HUHC), Fez during a period of 10 years (2010-2020). Among the 782 cases of gammopathies diagnosed by immunofixation (IF), 28 were shows biclonal gammopathies (3.5%), the sex ratio M/F was 1 and the median age was 63 years. The most frequent isotype was IgG/IgM with a slight predominance of the Kappa light chain. The most common diagnosis was biclonal gammopathy of undetermined significance (BGUS) in 12 patients (42%), followed by 10 cases of multiple myeloma (MM) (35%) and 6 cases of lymphoproliferative syndrome (21%). Although the clinical features are similar to monoclonal gammopathy, dentification of BGMs increases diagnostic precision in our region, in particular for multiple myeloma cases and lymphoproliferative syndrome compared to other studies.

Biclonal Gammopathies: A Retrospective Study in Hassan II University Hospital Center, Fez, Morocco