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Type 2 diabetes is a metabolic, progressive and chronic disease associated with β-cell dysfunction and insulin resistance that leads to a decrease in insulin production followed by a decrease in insulin secretion. The main objective of the study was to develop a mouse model for type 2 diabetes that resembles most of the features of human T2D along with SFRP4 expression. Initially, all parameters to be studied in the research were measured and recorded prior to the start of the experiment. In order to accomplish this model, two groups of mice were fed high fat diet (HFD) and two groups were fed low fat diet (LFD) and tap water for a period of twelve weeks. Mice exposure to HFD has shown diet-induced obesity. At the end of the feeding period, the serum lipid profile including triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and total cholesterol (TC) of all experimental animals was evaluated. Significant increase in serum levels of TG, TC and LDL while low serum HDL levels were detected in HFD-fed mice serum. Similarly, the serum-SFRP4 level of all animals was measured using the ELISA kit. The serum level of SFRP4 was shown to be elevated (P < 0.01) in mice fed with HFD compared to control objects (P < 0.01). SFRP4 was associated with a high risk of developing type 2 diabetes. In conclusion, HFD dietary manipulation induces obesity, hyperglycemia, abnormal lipid profile and significant SFRP4 levels that ultimately lead to type 2 diabetes. SFRP4 may be a potential biomarker for early detection of type 2 diabetes.

Establishment of Mouse Model for Obesity and Type 2 Diabetes and Expression of Secreted Frizzled Related Protein 4 (SFRP- 4) As A Biomarker