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Diabetes is a common cause of end stage renal disease and approximately 20 to 30% of all diabetics will develop nephropathy. Diabetic nephropathy is characterised by abnormal renal function with reduction of glomerular filtration and rise in the level of Serum Urea and Creatinine. The study was conducted at Princess Esra Hospital, Deccan College of Medical Sciences. Patients with Dm in the age group 35 Yrs – 55 Yrs and controls also of the same age group Glycosylated Haemoglobin (Hb A1C) was done to categorise patients into two groups. Patients with good glycemic control having HbA1c<6-7%, Studies have demonstrated that the complications of diabetes can be delayed or preventedif HbA1c can be kept between 6-7%. The other group of patients were having poor glycemic control with HbA1c above 8%. The following parameters were included in the study FBS, PLBS, HbA1cm Urea and Creatinine. These parameters were estimated in normal (controls) and diabetics (with good glycemic control) and diabetics (with poor glycemic control). It was found that the blood sugar, blood urea and serum creatinine levels were significantly higher in diabetic patients with poor glycemic control compared to diabetic patients with good glycemic control. Strong relationship of blood urea and serum creatinine levels was found with blood sugar and HbA1c levels. Blood urea, serum creatinine blood sugar along with HbA1c would be helpful to monitor the diabetes patients to assess renal function.

scholars international journal of biochemistry

Measurement of Urea and Creatinine as a Marker of Renal Function in Type 2 Diabetes Mellitus in Patients with Good Glycemic Control and Poor Glycemic Control