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Case Report Giant phyllodes tumors (PT) are those measuring more than ten centimeters. To date, there are eight cases of giant PT treated with mastectomy and breast reconstruction (BR) reported in the English literature. Almost all reports focused on the tumor size rather than the chest wall tissue defect size after tumor extirpation. While mastectomy is almost inevitable in all giant PT’s, none of the previously reported cases discussed on the impact of PT to the patient’s psychology and quality of life (QOL). We report a challenging giant PT case with the largest chest wall defect ever reported so far, treated with mastectomy and BR, with good cosmetic and psychological outcomes.

Challenging Breast Reconstruction after Excision of Giant Phyllodes Tumor with the Largest Ever Reported Soft Tissue Defect