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Case Report A 57-year-old housewife with primary biliary cirrhosis associated with scleroderma but without features of the calcinosis-Raynaud's phenomenon-sclerodactyly-telangiectasia syndrome is reported. The mechanisms responsible for the co-occurrence of these diseases are largely unknown. Genetic, epigenetic, environmental, and infectious factors appear to be important for the pathogenesis of the disease, but the hierarchy of events are not well defined. Some case reports suggested that the presence of SSc in PBC patents is associated with a more favorable prognosis of the liver disease, whereas others report an increased mortality in patients with PBC and SSc compared to patients with PBC alone.

Primary Biliary Chirrhosis Associated with Scleroderma: Case Report and Review of The Literature