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Original Research Article Background: Antimicrobial resistance is one of the major public health emergencies worldwide, and this trend didn’t spare developing countries like Bangladesh. Objective: To Evaluate The Blood Culture Profile And Antimicrobial Resistance Pattern: A Study In Intensive Care Unit (ICU) Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh. Methods: A hospital based observational study was conducted from April 2018 to May 2019 in Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh. A total of 303 neonates with clinical sepsis were included. Collected data were entered into EPI-INFO version 6.04(CDC, Atlanta, GA) for cleanup; and then exported to SPSS version 21.0 for further analysis. Frequencies and proportion were used to describe the study population in relation to relevant variables. Results: Bacterial growth was detected in 88 (29.4%) of blood cultures. Predominantly isolated bacteria were coagulase negative staphylococci (CoNS) 22 (25%), Escherichia coli (E.Coli) 18 (20.5%) and Staphylococcus aureus 16 (18%). Resistance rates of S. aureus and CoNS against Ampicillin were 11 (69%) and 20 (91%) respectively. The resistance rate of E. coli against Ampicillin and Gentamycin were 12 (66.7%) and 10 (55.6%) while Klebsiella spp. resistance rate gets much higher against these two first line antibiotics [10 (91%) and 9 (82%) respectively]. Similarly, both Gram positive and Gram negative bacteria isolates were also highly resistant to third generation Cephalosporins, and 63 (72%) isolated bacteria showed multidrug-resistance. However; Gram-positive bacteria isolates had better susceptibility patterns to third line antibiotics like Clindamycin, Vancomycin and Ciprofloxacin while Gram-negative isolates had a higher susceptibility to Ciprofloxacin and Amikacin. Conclusion: CoNS, S. aureus, E. coli and Klebsiella spp. were the leading bacterial causes of neonatal sepsis in our study. They were highly resistant to firstand second-line empiric antimicrobial treatment used at ICU (Intensive care unit), reducing the antimicrobial choices for management of neonatal sepsis. Fortunately, the mentioned isolated bacteria remained susceptible to third line antibiotics used to treat neonatal sepsis.

Blood Culture Profile and Antimicrobial Resistance Pattern: A Study in Intensive Care Unit (ICU) Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh