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Original Research Article Osteoarthritis of knee leads to disability and effects quality of life due to pain and deformity in advanced cases. Knee replacement is one of most successful surgery for osteoarthritis knee. This surgery improves pain and function of patient but is associated with substantial blood loss during and after the surgery. Tranexamic acid is commonly used to decrease post-operative blood loss by various routes i.e. oral, intravenous and intra-articular .Objective of study is to evaluate the effect of intra-articular Tranexamic acid on post-operative blood loss after unilateral primary total knee arthroplasty (TKA). A total of 50 patients of either gender planned to undergo unilateral total knee replacement (TKR) were enrolled in each of the two groups. In group A (Control group) no intra articular drug is injected. In Group B (study group), patients were given 2 gram intra articular Tranexamic acid. All patients were followed up to 72 hours from completion of surgery. Blood collection in negative suction drain was noted after every 24 hours. In the study group, the post-operative drainage blood loss was 550.36±72.81 significantly less (p<0.05) than those in the control group that was 1008.12±111.62. Intra-articular application of Tranexamic Acid is effective in decreasing the drainage blood loss after primary TKA treatment.

Effect of Intra Articular Tranexamic Acid Use on Post-Operative Blood Loss in Unilateral Primary Total Knee Arthroplasty (TKA)