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Original Research Article Fluoride poisoning is a severe health problem in many parts of the world where fluoride contamination in drinking water is more than 1.5 ppm of fluoride. The aim of the present study was to explore the effect of fluoride in different parameters of the blood and semen in order to investigate as a marker of fluoride toxicity. In the present study, 55 male fluorosis cases were recruited for the study. The seminal profile and trace metal ions were examined in the seminal plasma of the subject and controls. The mean values of the semen volume, viability, motility, viscosity, seminal pH, sperm density and liquefaction time were found to be changed significantly in the subject as compared to the age matched controls. The concentration of Zn and Se found to be reduced while Cu and Fe were increased significantly when compared with their respective controls. The higher intake of fluoride in ground water may be associated to adverse reproductive system. The investigation of metal ions and seminal profile are snapshot of the diagnosis of the assessment of the risk of fluoride toxicity.

Excessive Fluoride in Drinking Water Alters the Trace Metal Ions in the Seminal Plasma