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Original Research Article Objective: To evaluate the efficacy of Oral Vs Per-rectal Use of Misoprostol in Prevention of Third Stage Bleeding. Method: this observational prospective study was done at Tertiary medical college and hospital from March 2017March 2018. Total 100patients who got admitted into the Gynae and Obstetric department of tertiary medical college and hospital, for their delivery purposes were evaluated for study. Where the patients divided into two groups: groupA: orally used misoprostol; n= 51, group-2: pre rectally used misoprostol; n=49. Result: in the study, it was found that maximum patients belonged to 20-24 years group (51.4%). The next highest number of the patients was in 25-29 years group (29.7%).56% patients use misoprostol orally where only 44% use Misoprostol rectally. The t-test revealed that the mean blood loss (as measured by haemoglobin percentage) was significantly higher in per oral user group than that of per rectal users (p<.OOJ). That meant that per rectal use of Misoprostol could able to prevent more blood loss than oral use of Misoprostol tablet. Conclusion: from our study we can conclude that, rectal misoprostol is more effective in the management of third stage of labor. Lesser dose and other routes could be explored in the future.

Comparison between the Efficacy of Oral vs Per-Rectal Use of Misoprostol in Prevention of Third Stage Bleeding