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Original Research Article Introduction: Opium means juice, from Greek word. Morphine is named after Greek god of dreams, Morpheus Opioid refers to drugs derived from opium both natural and synthetics. Narcotic refers to morphine and like analgesics. Aim of the Study: To evaluate the effect of preservative free morphine 0.5mg administered intrathecally, on intraoperative anesthetic requirement and post operative analgesia in patients undergoing laparotomies under general anesthesia compared with multimodal analgesia during the 1 st 24 hours of postoperative period. Materials And Methods: This study was conducted at Sheikh Sayera Khatun Medical College & Hospital, Gopalganj, Bangladesh during from Jun to December 2019, in the general surgical operation theater.50 patients of ASA physical status I,II and III undergoing both upper and lower abdominal surgeries under general anesthesia are categorized into one of two groups, Group M – Morphine study group and Group C–Control group. In both study and control Group routine General anesthesia was administered. In Group M, 0.5mg morphine given intrathecally before general anaesthesia. The parameters studied were intraoperative hemodynamics, post operative pain score and analgesic requirement, post-operative hemodynamics, intra operative and post-operative complications. Results: The number of demand analgesia in 24 hours is 1.56 in Group – M vs 4.2 in GroupC and it is statistically significant (p=0.0002). Post operative visual analog score (VAS) in Group-M was 4.64 vs 5 in group – C. But it was highly significant at 2,4,8,12,20 hours and .However, it was not significant at postoperative zero hours, 14, 16,24 hours. Postoperative Ramsay sedation scale (RSS) is 2.16 in group – M, 1.6 in Group – C, this is statistically significant (P=0.0156). The postoperative heart rate in group –M vs Group – C are 85 ± 12.7 and 101 ± 13.9 respectively and it statistically significant (p=0.0002). The post operative mean arterial pressure (MAP) is 89 ± 15.7 groupM vs 104 ± 14.3 Group C which is statically significant (P=0.0012). Conclusion: Intrathecal morphine produced better postoperative analgesia and sedation. Intrathecal morphine group demonstrated lesser amounts of analgesic and rescue analgesic requirement during the postoperative period. Intrathecal morphine produced better hemodynamic stability in the postoperative period. Intrathecal morphine produced side effects in the form of nausea, vomiting, hypotension and bradycardia but not statistically significant.

Low Dose Intrathecal Morphine versus Multimodal Analgesia in Patients Undergoing Abdominal Surgeries under General Anaesthesia