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Original Research Article Introduction: Pain shares its etymological origin with words punishment and penalty and is the most miserable symptom of disease presentation. Pre-emptive analgesia is used as a treatment that is initiated before surgery in order to prevent the establishment of central sensitization evoked by the incision and inflammatory injuries occurring during surgery and in the early postoperative period. Role of Pregabalin and Flupirtine as pre emptive analgesia has been documented. The present study was undertaken to compare the role of Flupirtine and Pregabalin as pre-emptive analgesic in patients undergoing laparoscopic cholecystectomy because of their documented efficacy, cost effectiveness, pharmacokinetics and minimal side effects or complication. Material and Method: The randomised, double blind, prospective study was carried out in 100 patients scheduled for laparoscopic cholecystectomy and fulfilling the inclusion criteria at Indira Gandhi Institute of Medical Sciences, Patna. Two randomised groups were administered Flupirtine and Pregabalin as pre emptive analgesia and the postoperative outcome were compared and analysed. Results: The study population of both the groups were comparable with respect to age, gender and mean body weight, and the differences were statistically not significant. The Flupirtine group of patients had low postoperative pain score (VAS) in the period of evaluation postoperatively except at 6 th hour post operatively. The difference was statistically significant at 0 and 1 hours. The side effects were comparable among the two group and the difference was statistically not significant. Conclusion: Flupirtine in a single dose of 200 mg is better than single dose of 150 mg of Pregabalin when administered in the form of pre-emptive analgesia in patients undergoing laparoscopic cholecystectomy with lower VAS in immediate postoperative period and comparable side effects. Keyword: Pre-emptive Analgesia, Flupirtine, Pregabalin, Postoperative Pain. Copyright @ 2020: This is an open-access article distributed under the terms of the Creative Commons Attribution license which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use (NonCommercial, or CC-BY-NC) provided the original author and source

scholars journal of applied medical sciences

A Comparative Study of Role of Flupirtine and Pregabalin as Pre-emptive Analgesic in Patients Undergoing Laparoscopic Cholecystectomy a Prospective, Randomised, Double Blind, Clinical Study