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Humic acids (HAs) positively affect many body systems: excretory, digestive, nervous. In a few studies, the effect of HAs on the activity of the cardiovascular system is proved [Zykova, 2017; Lasukova, 2018]. With pathology of the heart and blood vessels, which annually take the lives of about 17 million people, there is a decrease in exercise tolerance due to the development of hypoxia. Due to the high mortality from cardiovascular disease, it is important to investigate the actoprotective activity of HAs. Materials and methods. HAs were isolated by alkaline extraction from sample of lowland wood-grass peats collected from «Tagan» deposit of Tomsk region [Zykova, 2013]. Physicochemical study of HAs carried out [Zykova, 2013]. Bioactivity of HAs was tested on 40 utbred male rats “Wistar” 250-300 g in autumn. The animals were divided on 4 groups of 10 animals each (Table 1). Solution of NaCl and HAs was administered intragastrically to experimental animals before 30 min swimming at the rate of 0.5 ml per 100 g of mass. As forced exercise used a forced swimming test [Pat. 2617206]. Upon completion of the five-day testing, all animals were withdrawn from the experiment by simultaneous decapitation under CO2-anesthesia. Decapitated animals collected blood to obtain serum. To assess the level of glycolytic processes during exercise, the rat serum lactate content was determined [Brancaccio, 2010; Brooks, 1999]. The concentration of lactate in the serum of the experimental and intact groups was determined by the colorimetric method [Dolgova, 2012; Kamyshnikov, 2000].

Actoprotector activity of humic acids low-mire wood-grass peat