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Biofunctional nanostructured systems have attracted much attention since can have applications as replacement or supplement of deficient cells, drug delivery, medical imaging and therapy. They are engineered and non-restricted structural materials that mimic some functions, surface characteristics, shapes, and even morphology of biological cells. Mimicking surface characteristics provides an efficient way to emulate functions of template cellular systems. In addition, systems with unique and similar shape and mechanical properties to cells are also able to replicate some cellular functions. In recent literature, there are also several reports about constructing materials that replicate ultrafine morphological features of biological cells. Although constructing ‘totally living’ artificial cellular systems is still farfetched, the progress toward this ultimate goal will likely present many benefits and new biomedical applications.This article presents an overview on recent advances in the design of biofunctional nanostructured systems, highlighting synthesis strategies and their main biomedical applications in different Nanomedicine fields. Key-words: Biofuntional nanostructured systems, biomedical application, biomaterial, nanomedicine.

Sistemas Nanoestruturados Biofuncionais: Estratégias de Síntese, Tecnologias e Aplicações em Nanomedicina