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The discovery of adult neurogenesis in human dentate gyrus of the hippocampus opens new challenges on the role of a virtuous lifestyle (i.e. diet) aimed at counteracting/slowing the decay of new neurons production in the aged brain. The use of probiotics could represent an intriguing approach for the prevention of specific diseases. Lactobacillus farciminis Reuter (ATCC 29644) supplementation: • Active on colonic inflammation, visceral pain and prevention of intestinal barrier impairment. • Able to attenuate HPA response to an acute psychological stress in rats, and to decrease the associated neuroinflammation, through the prevention of stress-induced gut leakiness and LPS upload. • Anti-inflammatory properties, through mechanisms principally linked to the release of nitric oxide in the colonic lumen. 1st aim: To study the potential neuroprotective effect of prolonged consumption of Lactobacillus farciminis (LF), in a mouse model of acute neuroinflammation.

Effect o Lactobacillus farciminis supplementation in preventing LPSinduced hippocampal neuroinflammation, in mice