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Chronic otitis media (COM) with or without cholesteatoma is a major global health problem, especially in developing countries. Until today, there is no other treatment for COM with cholesteatoma (COMch) other than surgery. Puguntano (Curanganfel-terrae Merr) is a plant from Scrophulariaceae family. It can be found in Asia, especially in China, India, Philippines, Myanmar, Malaysia and Indonesia. This plant has traditionally used as stimulant, antidiuretic, treatment for malaria, hepatoprotective drug, antipyretic, antiherpetic drug, anti-cancer, antihyperglycemic, antioxidant and anti-inammatory. The objective of this study is to evaluate the effect of ethanol extract from Puguntano leaves on Interleukin-1α expression level in cholesteatoma matrix cultures with atticoantral type chronic supurative otitis media. This study is an in vitro experimental research comparing two groups, a keratinocyte cholesteatoma culture with and without Puguntano extract. A group without extract Puguntano was divided into 4 different groups: group with Puguntano extract 1 mg/ml, 2 mg/ml, 4 mg/ml and control group.Interleukin-1α level in cholesteatoma culture is inversely proportional to Puguntano extract. Interleukin-1α expression level in group with Puguntano extract 1 mg/ml is 4,335 pg/ml; 2 mg/ml is 3,83 pg/ml; and 4 mg/ml is 2,74 pg/ml. Those results showed the decreasing level of Interleukin-1α expression compared to control group, which is 8,2889 pg/ml.

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EFFECT OF PUGUNTANO LEAF EXTRACT (CURANGAFEL-TERRAE MERR) ON INTERLEUKIN-1α EXPRESSION OF CHOLESTEATOMA MATRIX CULTURES WITH ATTICOANTRAL CHRONIC SUPURATIVE OTITIS MEDIA