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Background and objective: in the global scientific literature, the frequency of JAK2 is highly heterogenous in chronic myeloproliferative neoplasms. The objective of this study was to analyze the prevalence of the JAK2 mutation in primary myelofibrosis (PMF) and compare it according to the detection method used, from 2007-2018. Materials and methods: a systematic review with meta-analysis, using 21 searches in three multidisciplinary databases. The PRISMA guideline phases of identification, screening, selection and inclusion were applied. Reproducibility and evaluation of the methodological quality were ensured. The analyses were based on frequencies and meta-analysis for the prevalence of the mutation with its 95% confidence interval. Results: twenty-nine studies with 744 patients were included, mainly from Korea, Brazil and China. The most commonly used technique was AS-PCR, and the prevalence of JAK2 with this technique ranged from 33.3 to 71.4%; with real-time PCR ranging from 42.9 to 77.3%, sequencing Metaanálisis de la frecuencia de JAK2 en mielofibrosis primaria según la técnica de detección Meta-analysis of the frequency of JAK2 in primary myelofibrosis according to the detection method used Mónica Mejía-OchOa, PaOla andrea acevedO-TOrO, jaiberTh anTOniO cardOna-arias • Medellín (ColoMbia) Dra. Mónica Mejía-Ochoa: Bacterióloga, MSc(C) Microbiología y Bioanálisis-Énfasis Hematología. Grupo de Investigación Hematopatología Molecular, Escuela de Microbiología Universidad de Antioquia; Dra. Paola Andrea Acevedo-Toro: Microbióloga y Bioanalista, MSc Ciencias Básicas Biomédicas. Grupo de Investigación Hematopatología Molecular, Escuela de Microbiología Universidad de Antioquia; Dr. Jaiberth Antonio Cardona-Arias: MyB, MSc Epidemiología, MSc Economía Aplicada, PhD (candidato) Salud Pública. Escuela de Microbiología Universidad de Antioquia. Facultad de Medicina Universidad Cooperativa de Colombia. Medellín (Colombia). Correspondencia: Dr. Jaiberth Antonio CardonaArias. Medellín (Colombia). E-mail jaiberthcardona@gmail.com Recibido: 30/VIII/2019 Aceptado: 07/X/2020