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Purpose: The purpose of this article is the systemic modernization of scientific ideas relating to the essential factors and conditions of functioning and development of regional socioeconomic systems. Design/Methodology/Approach: To substantiate the article about the possibility of overcoming the socio-economic stagnation and recession of the region's economy based on modernization of research tools and management of local and regional socio-economic processes using modern agglomerative technologies and methods. Findings: Finding lies in clarifying the arrangement, structure and importance of socioeconomic processes, factors and conditions of local, regional and interregional level that determine the effectiveness and sustainability of functioning of the economy. Practical Implications: Are determined by the possibility to use authors’ scientific results for audit, evaluation and adjustment of regional socio-economic impacts, measures and development programs, used during designing, forecast and assessment of socio-economic and complex efficiency of local and regional socio-economic activeness in the cities and municipal areas. Originality / Value: It is substantiated by development of the theory and methodology of regional studies of socio-economic factors and conditions that determine long-term prospects of stable functioning and sustainable development of the regional economy on the basis of adaptation of the basic direction of the system and reproduction processes.

Factors and Conditions of Functioning and Development of Modern Regional Socio-Economic Systems