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Melanocytes in basal layers of skin and hair follicles produce melanin biopolymers which determine phenotypes of skin and hair colors of an individual. Melanogenesis induction is influenced by many factors: one of them is activation of receptors in melanocytes’ trans-membrane fragments by effector hormones. Melanocortin-1 receptors belong to the subclasses of the G-protein-coupled-receptor (GPCR) family that is located in melanocytes’ transmem-brane fragments. Variations of their protein structures affect the end result of skin color. Intro-duction, nomenclature, grouping these receptors in the GPCR family, and their protein struc-tures, give some important information about how the receptors actually work in our body, especially in the skin and hair. Key words: GPCR, MC1R, protein’s structure. Abstrak: Sel-sel melanosit pada lapisan basal kulit dan folikel rambut memproduksi biopoli-mer melanin yang akan menentukan fenotip warna kulit dan rambut seseorang. Induksi melanogenesis yang terjadi dipengaruhi oleh banyak faktor, salah satu diantaranya adalah melalui aktivasi reseptor pada transmembran melanosit oleh beberapa hormon efektor. Reseptor melanokortin 1 merupakan sub-sub kelas kelompok reseptor protein G yang terletak pada transmembran melanosit dimana variasi struktur protein penyusunnya akan mempengaruhi hasil akhir warna kulit. Pengenalan awal, tata nama, penggolongannya  dalam bagian keluarga besar protein G serta struktur protein setidaknya memberi sedikit pemahaman bagaimana cara kerja reseptor ini selanjutnya. Kata kunci: MC1R, GPCR, struktur protein.

RESEPTOR MELANOKORTIN 1 (MC1R) ASAL USUL DAN STRUKTUR PROTEIN