English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Uric acid has low water solubility. When the concentration exceeds its solubility, it will form monosodium urate (MSU) crystals which can trigger inflammation. High sensitivity C-reactive protein (hs-CRP) is one of the most liable inflammatory biomarker and recently considered as major modifiable risk factor of coronary heart disease. Serum uric acid and hs-CRP levels are often elevated in obese patients. The purpose of this study are to determine hs-CRP and serum uric acid levels and to determine the correlation between serum uric acid and hs-CRP  levels in obese adolescents. This is an analytic observational study with cross sectional design. Subject consist of 17 obese adolescents age 17-20 years with percentile of ≥ 95 in CDC BMI-for-age chart. Nonparametric analysis with Spearman test was applied to find the correlation between serum uric acid and hs-CRP levels. The mean serum uric acid and hs-CRP levels in obese subjects were 7.37 (SD 1.66) mg/dL and  1.73 (SD 1.44) mg/L respectively. In conclusion, a statistically insignificant correlation between serum uric acid and hs-CRP levels was found (p = 0.296, r = 0.14). Serum uric acid levels  are consistently higher in obese adolescents. Hs-CRP levels among obese subject shows moderate risk of developing cardiovascular disease in the future. Keywords: Adolescents, hs-CRP, obese, serum uric acid Abstrak: Asam urat memiliki kelarutan yang rendah dalam air. Saat konsentrasi asam urat melebihi batas ambang solubilitas, akan terbentuk kristal monosodium urat yang akan memicu inflamasi. High sensitivity C-reactive protein (hs-CRP) merupakan salah satu biomarker inflamasi yang belakangan ini dijadikan faktor risiko mayor yang dapat dimodifikasi dari penyakit jantung koroner. Kadar asam urat serum dan hs-CRP biasanya meningkat pada penderita obesitas. Tujuan dari penelitian ini untuk mengetahui hubungan kadar asam urat serum dengan hs-CRP serta gambaran kadar asam urat serum dan hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional  dengan pendekatan cross-sectional. Subjek terdiri dari 17 remaja obes usia 17-20 tahun dengan persentil ≥ 95 pada grafik IMT terhadap usia CDC. Analisis data menggunakan Spearman test digunakan untuk mengetahui korelasi antara kadar asam urat serum dengan hs-CRP. Nilai rata-rata kadar asam urat serum dan hs-CRP yang didapat secara berurutan mencapai 7,37 (SD 1,66) mg/dL dan 1,73 (SD 1,44) mg/L. Sebagai kesimpulan, hubungan kadar asam urat serum dengan hs-CRP tidak signifikan (p = 0,296) dan berkorelasi positif lemah (r = 0,14). Kadar asam urat serum pada remaja obes tergolong tinggi. Kadar hs-CRP remaja obes termasuk dalam risiko menengah untuk terkena penyakit kardiovaskular di masa mendatang. Kata kunci: Asam urat serum, hs-CRP, Obesitas, Remaja

HUBUNGAN KADAR ASAM URAT SERUM DENGAN KADAR HIGH-SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES