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Background: Pregnancy-induced hypertension is a leading cause of deleterious changes in the placenta resulting in decreased blood supply towards the organ. The objective of the current study was to analyze the histomorphometric variations in the placenta of normotensive and hypertensive women in a tertiary care hospital of Hyderabad, Pakistan. Material and Methods: This cross-sectional study was carried out in the Gynecology and Obstetrics section of Nazeer Hussain Medical Complex, Hyderabad in collaboration with Isra University, Hyderabad Pakistan from March 2019 to August 2019. A total of 100 placentae were collected and divided into two groups. Group I had placentae of normotensive women and group II comprised of placentae of hypertensive women. All the placentae were observed for morphometric and histological changes. Student t-test was done to study morphometric differences between the two groups, while chi-square test was used to analyze the categorical variables. P-value < .05 was considered as statistically significant. Results: There was an increase in the mean weight of placentae among group I as compared to group II and the difference was statistically significant (P < .05). Various gross and histological changes (hyalinized villi, intervillous hemorrhage, decreased villous vascularity) with a statistically significant difference were also observed in the placentae of the hypertensive group as compared to the normotensive placentae (P < .05). Conclusions: This study concluded that pregnancy-induced hypertension poses harmful and serious histomorphometric variations in the placental tissues that may affect fetal outcome.

Histomorphometric Variations of the Placenta in Normal and Hypertensive Pregnancies