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This research was conducted to estimate exposure and risk of exposure to BTEX (benzene, toluene, ethylbenzene  and  xylene)by  a  cross-sectional  studying  among  pregnant  women  who lived in the vicinity of a petro-chemical industrial estatearea. Personal exposure was monitored by  environmental  and  biological  sampling.Other  relevant  data  were  gathered  by  a  structured questionnaire for analysis. The relationship between BTEX exposure and potential risk factors was  determined  by  multiple  linear regression. Average  BTEX  exposure  levels  were  18.89, 29.40,  10.26,  and  17.85μg m-3,  respectively, which  were  significantlyhigher  than  the  control group. Urinary metabolite levels of muconic acid(t,t-MA), hippuric acid (HA),mandelic acid (MA), andmethyl-hippuric acid (mHA)were significantly higher in pregnant residents living in the  vicinity  of  the  petro-chemical  industrial  estate  area.The  correlation  between  women’s individual  exposure  to  BTEX  and  theirurinary  metabolites  showed significantlydifference between groups.Risks of benzene and ethylbenzene exposure for these pregnant subjects were approximately  4.37x10-7 and  1.92x10-8lower  than  the  acceptable  limits  of  United  States Environmental Protection Agency(US.EPA.) guidelines(10-6). The hazard index (HI) of these pregnant  subjects  a  lifetime  rate was  0.555  which  was  below  the  reference  level(HI  &lt;  1).Multiple  linear  regression  analysis  found  that t,t-MA, HA, MA, and mHAin  the  urine  of  all models  were  significantly  (p&lt;0.05)and  positively  related  with BTEX  in  ambient  air.The study  showed  that  there  was  a  low  cancer  risk  for  pregnant  women  in  the petro-chemical industrial  estatezone. However, when  compared  with  the  control   area,   a  statistically significant difference was found in the relationship between BTEX content in ambient air and metabolites   in   the   urine   of   pregnantwomen. The   implication   is   that   the   responsible government agencies should implement health surveillancecontinuously.

Exposure to BTEX and Assessment of the Potential Risk among Pregnant Residents Living in the Vicinity of a Petro-chemical Industrial Estate