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Objective: To evaluate in vitro the antifungal activity of total extracts from the leaves of Hugonia platysepala, a medicinal plant in southwestern Côte d'Ivoire in order to treat the fungi of people in poor countries infected with HIV/AIDS at a lower cost. Methodology and results: The liquid dilution macromethod and solid-media scattering method have been used for antifungal testing. The results revealed that both water extracts (ETA) and hydro alcoholic (ETOH) have fungicide activity on Cryptococcus neoformans and Candida albicans but ETOH extract is 32 times more active than ETA extract with a 1.56 mg/ml CMI and CMF 50 mg/ml. Tested on an isolate of Candida albicans resistant to Amphotéricin B and Fluconazole, ETOH obtained an inhibition zone above the 10 mm sensitivity threshold. Conclusion and application: ETOH therefore has a fungicide effect on strains of Cryptococcus neoformans and Candida albicans, sensitive or resistant to conventional antifungals regularly prescribed to patients. The phytochemical screening of this ETOH extract revealed the presence of terpenes and polyphenols that could justify its antifungal pharmacological properties. The ETOH extract of Hugonia platysepala, after purification of its active molecules, can be used as an Improved Traditional Drug in the treatment of fungus in HIV-infected people.

journal of applied biosciences

Evaluation de l’activité antifongique des extraits totaux de Hugonia platysepala sur les pathogènes responsables de cryptococcoses et de candidoses chez les sujets infectés par le VIH