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Objectives  to provide scientific evidence for rational use of herbal medicines in otorhinolaryngological practice.&#x0D;Material and methods. The study included the following plants: Eucalyptus viminalis leaves, Monarda fistulosa herbs, Melissa officinalis herbs, Echinacea purpurea herbs, Calendula officinalis flowers, rhizomes of Rhodiola rosea, rhizomes of Eleutherococcus senticosus, Glycyrrhiza glabra roots, Macleaya microcarpa herbs, Macleaya cordata herbs, Plantago major leaves, Origanum vulgare herbs, Thymus serpyllum herbs. Phenylpropanoids, flavonoids, euglobals, monoterpene phenols, phenylpropanoids, terpenoids of essential oils, saponins and alkaloids were isolated from the medicinal plants and studied with thin-layer chromatography, spectrophotometry, NMR spectroscopy, mass spectrometry, and various chemical transformations.&#x0D;Results. It was scientifically proved that medicinal plants containing such biologically active compounds as phenylpropanoids, flavonoids, euglobals, terpenoid and phenolic components of essential oils, saponins, carotenoids, alkaloids and polysaccharides are useful for otorhinolaryngology. The active substances of the mentioned chemical groups in combination can provide antimicrobial, antifungal, antiviral, anti-inflammatory, regenerating, antihistamine, adaptogenic and immunomodulatory effects.&#x0D;Conclusion. The expediency of using medicinal herbal preparations containing euglobals, monoterpene phenols, flavonoids, phenylpropanoids, terpenoids of essential oils, saponins, alkaloids and polysaccharides in otorhinolaryngological practice was scientifically justified.

Scientific evidence for efficiency of medicinal plants in otorhinolaryngology