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I n t R o D U C t I o n Poisoning is one of the most important issues of forensic medicine. Clozapine is an example of so called atypical neuroleptics [1]. The therapeutic threshold of this drug is comparatively narrow. A single therapeutic dose of this drug is 50–200 mg, the highest daily dose is 900 mg., whereas a fatal dose for an adult is about 2 g [2]. Clozapine is widely used in clinical practice to treat acute and chronic forms of schizophrenia, psychosis, manic conditions, bipolar disorders, aggressiveness and others [3]. More than one million people in more than 60 countries of the world undergo treatment with clozapine annually. All the facts mentioned above determine a high risk of clozapine poisoning. The number of criminal clozapine intoxications in Russia also remains high. Such poisonings are characterized by severe symptoms and high mortality.

HISTOMORPHOLOGICAL CHANGES IN THE KIDNEYS IN CASE OF CLOZAPINE POISONING