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A study has been made on the formulation and evaluation of promethazine hydrochloride suppositories using dika fat (DF) from Irvingia gabonensis seeds as a base comparatively with both water and fatty soluble bases. Rectal suppositories containing promethazine hydrochloride (25 mg) in pre-calibrated mould were prepared by fusion method using DF, macrogol (MG), cocoa butter (CB) and cocoa butter + 10%w/w (weight by weight) beeswax (CBW) as bases. Thereafter the suppositories were characterized using parameters such as appearance, crushing strength, weight variation, melting point, pH, liquefaction time, content uniformity, and in vitro release in accordance with standard procedures. Results obtained indicated that the bases used generally could be ranked in the order of DF > CB > MG > CBW in terms of favourable physicochemical properties investigated. The foregoing indicates that DF has promising potential and could be a substitute suppository base in the formulation of promethazine hydrochloride suppositories

Comparative evaluation of Irvingia gabonensis seed fat extract and other bases in promethazine hydrochloride suppository formulations