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Hantavirus infection is a worldwide neglected zoonotic disease, affecting 200,000 people/year, mainly transmitted to humans through the inhalation of contaminated aerosols, saliva and/or urine of infected rodent animals. The clinical manifestations of the disease in humans mainly include hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). These syndromes are correlated to hantavirus genotypes and they are intimately associated to rodent reservoirs that have a specific geographical distribution worldwide. HFRS is caused by Old World hantaviruses, like Seoul virus. However, despite the report frequent occurrence of HFRS in Eurasia and infrequent diagnosis of disease in Americas, Seoul virus was isolated in rodent samples and specific antibodies against this genotype were found in serum from patients with suspected leptospirosis in Brazil. On this context, the presence of Rattus norvegicus allied to the previous report of Seoul virus in Brazilian territory, remarks however the urgency of development of novel diagnostic tools in order to detect hantavirus genotypes associated with HFRS, to avoid the misdiagnosis of this syndrome as other bacterial or viral hemorrhagic fevers. Besides, hantavirus nucleocapsid protein (NP) is the major antigen that elicits early serological responses in infected humans and has been used as a biomarker to develop antibodies for epidemiological surveillance in regions where various hantavirus species cocirculate. However the identification of B-cell epitopes on NP remains unexplored. Objective: To identify immunogenic B-cell linear epitopes in the nucleocapsid of hantavirus genotypes associated to HFRS.

anais do iv international symposium on immunobiological e vii seminário anual científico e tecnológico de bio-manguinhos

Identification and experimental validation of immunodominant B-cell epitopes present on hantavirus genotypes associated to hemorrhagic fever and renal syndrome