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Vaccination against influenza plays a key role in a verting severe disease and reducing morbidity, mortality and the socioeconomic costs al lied with primary and secondary infections. Since trivalent Influenza B vaccine com prises only a viral lineage, a successful intervention relies on the agreement between circul ating viruses and vaccine-selected strains. Furthermore, available data show two yearl Inf uenza epidemic peaks in Brazil, whereas national vaccination campaigns are carried out in a single period, after the first epi-peak in the North and part of Northeast regions .

Challenges in Influenza B vaccination in Brazil: from vaccine mismatches to viral evolutionary dynamics