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Yellow Fever (YF) vaccine is a golden standard immunobiological in terms of effectiveness and safety. Even though, rare cases of neurological or viscerotropic adverse events following immunization (YEL-AD) occurs few days after vaccination due to Human Inborn Errors of Innate Immunity (HIEII). Previous works have characterized YEL-AD cases presented mutations within IFNAR1 gene, or autoantibodies anti-IFNα, impairing type I interferon (IFN) response, the main antiviral pathway and innate hub. From the immunological point of view, it is known that YEL-AD lead to normal humoral responses, therefore cellular innate functional investigations are mandatory to understand the consequences of HIEII and help to formulate therapeutic strategies. Here, we report an analysis of innate cells, innate immune mediator’s profile, and transcriptomics in cases from a national-based, YEL-AVD phase IV study.

Abnormal cellular innate responses in cases of adverse events post yellow fever immunization after in vitro 17DD stimulation