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Objective: Here we demonstrate how the new Prometheus PANTA by NanoTemper Technologies can be used to completely characterize the behavior of proteins in solution and predict the long-term stability of biologics using a combination of thermal unfolding, turbidity measurement, and colloidal stability. This new developed instrument has been design with 3 detectors to giving the capability to measure, simultaneously, the unfolding, turbidity, particle size and polydispersity index (PDI), without affecting the data quality.

Improve Biologics stability in solution understanding the colloidal and conformational stability