English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Chimeric antigen receptors (CARs) are formed by three components: an extracellular domain, a transmembrane domain, and an intracellular domain. These receptors can be introduced into human T cells to redirect antigen specificity and improve function in passive immunotherapy. The extracellular domain is responsible for antigen recognition, which is usually formed by a single chain fragment variable (scFv); and a spacer (hinge). The main function of the transmembrane domain is to connect the extra and intracellular domains of a CAR and, as well as the hinge, may influence the CAR T cell effective function. The intracellular domain is the activating portion of T cells, usually formed of CD3-ζ. Immunotherapy using anti-CD19 CAR T cells is an effective treatment for B cells leukemia and lymphoma. CD19 is expressed on malignant B cells and is therefore a potent marker of cancer cells.

Proposed mechanism for signal transduction of a CAR model in interaction with CD19, a cancer cell marker