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An innovative skincare product line incorporating a proprietary blend of selected peptides and botanicals formulation has been developed with the aim of preparing skin surfaces for rejuvenating procedures and for their long-term maintenance. The premise is to clear the extracellular matrix (ECM) of accumulated waste products improving cellular ECM cross talk enabling efficient collagenesis and elastogenesis to follow. Methods: To validate this scientific narrative and examine efficacy without the use of rejuvenating devices, we have undertaken a series of histological examinations in 5 subjects in their 60s assessing changes following isolated topical application of product to the skin. Results: From a histological perspective, our findings showed significant changes within the ECM, with new collagen formation and increased elastin, a ‘healthier’ epidermis with healthy cuboidal basal stem cells at the dermoepidermal junction, a thickened epidermis and increased procollagen levels within the newly created ECM. This was evident in all patients in varying degrees. Conclusion: It is apparent that in periods as short as 3 weeks, histological changes can be initiated purely by topical application of this proprietary blend of peptides and botanicals. This validates the use of these products as preconditioning for procedures and in conjunction with the use of rejuvenating devices

Histological Changes Associated with Extracellular Matrix-Remodeling Topical Therapy