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Dysbiosis in the gut microbiota has been observed in a various autoimmune disease, including SLE, which could  cause a leaky gut, triggering an immune response, and thus worsening autoimmune disease expression. In our current  studies, we hypothesized that increasing dietary fiber would create a healthy microbiota environment in the gut,  leading to decreased leakiness of the gut and to decreased disease expression in and NZB/NZW female lupus-like  mice. NZB/NZW mice were placed on standardized high fiber (HF 30%) or low fiber (LF 0.4%) for 12 weeks  beginning at 20 weeks of age. Mice were assessed as they aged for various parameters of disease including proteinuria  and anti-dsDNA antibody production. Alteration of the microbiota and short chain fatty acid (SCFA) levels were also  assessed. At 36 weeks-of-age, the mice were euthanized, and we assessed occlusion protein expression, splenocyte  profiles, and kidney tissue. We found as the mice aged, their body weights, anti-dsDNA antibody levels, and  proteinuria were not significantly different between the groups. Similarly, there were no significant differences in  SCFA levels. Regarding the microbiota, Chlostridiales bacteria were consistently increased in the HF treated mice  compared to the LF treated mice. Furthermore, as the mice aged, disease progression as assessed by - spleen weight,  immune cell profiles, proteinuria, dsDNA levels, and kidney pathology, was not different between the HF and LF  treated groups. Taken together, these results indicate that in the NZB/W female lupus mouse model, a HF diet may alter the microbiota but does not influence disease progression.

The Effect of Dietary Fiber Intake on Systemic Lupus Erythematosus (SLE) Disease in NZB/W Lupus Mice