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II Abstract In the context of this master thesis in vivo tests with porcine blood were repeated in the form of in vitro tests with water. In both test campaigns the CO2 separation efficiency of an oxygenator prototype was determined. It could be shown that water has similar CO2 removal rates as blood despite lower CO2 binding capacity and lower viscosity. Computational Fluid Dynamics (CFD) simulations were performed to investigate the influence of the binding capacity and viscosity on the concentration polarization in the boundary layer. The concentration polarization which occurs on the blood side of the membrane surface is of particular interest. It is the limiting factor and dominant resistance for the CO2 separation rate. The CFD simulations performed with the opensource program OpenFOAM® and the in-house developed solver membraneFOAM allow to determine the thickness of the concentration polarization and the CO2 removal rate. The CO2 removal rate can also be determined by Sherwood correlations. In this work the empirical parameters of a Sherwood correlation were determined. For this purpose, the CO2 removal rate of the oxygenator prototype determined in vitro with water was used. Furthermore, a method is evaluated which allows the conversion of the transport resistance and thus the CO2 removal rate with water to that with blood. The conversion is performed by a suitable adjustment of the material parameters in the Reynolds and Schmidt numbers, which are contained in the Sherwood correlation. Table of contents III Table of contents Kurzfassung  I Abstract  II Table of contents  III

Suitability of water as a blood model for the quantitative determination of the CO2 separation rate of membrane oxygenators